Current location: Home > PRODUCTS > Real Time PCR Series Products

PRODUCTS

Human EGFR Gene Mutations Detection Kit

Human EGFR Gene Mutations Detection Kit

Real Time PCR

CE-IVD



Individualized targeted therapy: Using new methods of molecular analysis, to help doctors and patients choose the most effective drugs, and to better control the disease progression according to the patient's genetic characteristics, thus to develop a suitable personalized therapy.


EGFR is a transmembrane receptor tyrosine kinase, which could be activated by anto phosphorylation upon ligand binding, the activation of EGFR contributes to promote cancer cell proliferation and relevant signal transduction significantly.The status of EGFR gene mutation is the most important factor for predicting EGFR-TKI efficacy, which is the prerequisite for determining whether the EGFR-TKI therapy is suitable for the specific patients.






Detection Items


GeneGene StatusDrug Indications
EGFR

exon 18,19,21

mutations(19Del,

L858R,G719X,

S768I,L861Q)

The first /second generation of

EGFR-TKI drugs:

Gefitinib

Erlotinib

lcotinib

Dacomitinib

Afatinib

sensitive

exon 20 mutation

(T790M)

Osimertinibresistance

exon 20 mutation

(20-Ins)

The first generation of

EGFR-TKI drugs
resistant


Performance Parameter


Product Name Technology Product Specification Matched InstrumentSample Type

Human EGFR Gene 

Mutations Detection Kit

PAP-ARMS®

10 tests/kit


Stratagene

Mx3000pTM,

ABI7500 etc.

tumor tissue slice,

ct DNA,

pleural effusion


Detection Signification


Personalized medicine selectionguidance: A detection result can help the doctors select suitable target drugsand assist the doctors make the judgement about the EGFR-TKI resistance/sensitivity.



Product Highlights


Stable and Reliable:Closed tube detection, avoid contamination.

High SensitivityThe detection can reach as low as 1%in 10 ng DNA.

Easy OperationOne step operation, only 90 minutesto finish the detection.

Good Reproducibility:Can be performed in the general PCR Labs. Results with good reproducibility canbe easily obtained without special training.

Advanced TechnologyR&D based on independent patented PAP-ARMS® technology.



Detection Process