EN
Methylguanine DNA-Methyltransferase (MGMT) is a highly effective DNA repair enzyme that can repair damage to the DNA of tumor cells caused by alkylating agents in chemotherapy and if the MGMT activity in tumor cells reaches a certain level, it may lead to drug resistance. MGMT's repair function of alkylating agent damage enables it to play a dual role in tumor chemotherapy: First, it protects normal tissue from alkylating agent damage and secondary cancer; Second, it causes the resistance of tumor tissue to alkylating agent chemotherapy drugs. MGMT's repair of alkylating agent damage enables it to play a dual role in tumor chemotherapy: First, it protects normal tissue from alkylating agent damage and secondary cancer; second, it causes the resistance of tumor tissue to alkylating agent chemotherapy drugs.
DNA methylation is closely related to the occurrence and development of brain glioma. The "Tumor Individualized Therapy Detection Technique Guideline" indicates that glioblastoma patients with methylated MGMT promoter benefit from Temozolomide.
MGMT methylation suggests sensitivity to Temozolomide chemotherapy, which is helpful for clinical formulation of appropriate treatment
MGMT methylation suggests a better prognosis
Glioma WHO III/IV glioma patients or before chemotherapy treatment.
Accurate and reliable
Closed tube detection without product post-processing.
Simple operation
Only one step, 90 minutes to complete the test.
Good repeatability
The ordinary PCR laboratory can be carried out, and no special training is required to obtain good repeatability results.
Advanced technology
Developed based on proprietary PAP-ARMS® technology.
1.Nucleic acid extraction
2.Set up qPCR
3.Amplification
4.Data analysis
5.Report generation
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