Solid Tumors 107 Gene Mutations Detection Kit
Next Generation Sequencing
Solid Tumors 107 Gene Mutations Detection Kit
It is suggested that patients have sensitivity and drug resistance to targeted drugs ; Assess the prognosis of patients ; Immunotherapy markers, positive and negative regulators of immunotherapy, and super progression factors were detected to comprehensively evaluate the benefits of PD-1 / PD-L1 immunotherapy. Suggesting the efficacy and side effects of chemotherapy drugs.
BACKGROUND

The International Agency for Research on Cancer ( IARC ) has released the latest statistics on the global cancer burden ( based on data for 2022 ), and once again highlighted the current increasing global cancer burden, which deserves worldwide attention. According to the report, in 2022, there are an estimated 20 million new cancer cases worldwide, and about 9.7 million people died of cancer. It is estimated that the number of survivors within 5 years after cancer diagnosis is about 53.5 million. About 1/5 of people will have cancer in their lives, about 1/9 of men and 1/12 of women died of cancer .It is estimated that by 2050, there will be more than 35 million new cancers worldwide.


Cancer is a complex, multi-gene disease caused by the gradual accumulation of genetic mutations. When genes that regulate cell growth undergo mutations or damage, cells lose control and undergo uncontrolled and unlimited proliferation and differentiation, leading to the development of malignant tumors.


With the advent of precision medicine in cancer treatment, conventional pathological diagnostic methods are no longer sufficient to meet clinical demands. International guidelines and consensuses recognize the value of comprehensive molecular testing based on Next-Generation Sequencing (NGS) in guiding clinical treatment. Comprehensive and accurate tumor genetic diagnostic results have become an essential requirement in clinical diagnosis and treatment.


BACKGROUND
DETECTED GENES

PRODUCT INFORMATION
Product Name
Core Technology
Pack Size
Instruments Validated
Sample Type
Solid Tumors 107 Gene Mutations Detection Kit
RingCap®
16 Tests/Kit;32 Tests/Kit
Illumina, MGI, Sikun,etc.
Tumor tissue,Pleural effusion&Ascites
APPLICABLE POPULATION

1.The detection of newly diagnosed solid tumor patients before targeted therapy, immunotherapy and chemotherapy can assist clinicians in formulating treatment plans and evaluating the prognosis of patients.;

2.Targeted therapy for patients with drug-resistant and chemotherapy-failed solid tumors requires new treatment options, genetic testing, identification of drug resistance mechanisms, and search for new operable sites.

DETECTION SIGNIFICANCE

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FEATURES & ADVANTAGES
Easy & Fast

Easy & Fast

With patented RingCap® technology, Library preparation in 2 steps. The library preparation takes only 3.5 hours.

Accurate Detection

Accurate Detection

DNA + RNA-NGS double detection, improve the fusion detection rate, expand the target treatment benefit population.

High Sensitivity

High Sensitivity

Gene mutations as low as 1 % in DNA samples and fusion mutations as low as 200 copies in RNA samples can be detected.

Comprehensive Coverage

Comprehensive Coverage

Covering genes with important clinical significance in the diagnosis and treatment of solid tumors, covering tumor-related gene mutations, amplification and rearrangement ( fusion ) and other variation methods, to meet the needs of clinical detection in an all-round way.

Strict Quality Control

Strict Quality Control

Quality control measures are implemented at various stages, including nucleic acid extraction, library preparation and data analysis, ensuring rigorous quality standards are maintained.

DETECTION PROCESS

1. Nucleic Acid Extraction

2.  Library Preparation (3.5 hours total time)

3. Sequencing

4. Auto-data Analysis

5. Report