KIAA1549-BRAF Fusion Gene Detection Kit
Multiplex Fluorescence Polymerase Chain Reaction
KIAA1549-BRAF Fusion Gene Detection Kit
KIAA1549-BRAF gene fusion is one of the most common driver gene mutation in pediatric low-grade gliomas. Patients positive for this fusion exhibit higher tumor proliferative activity and significantly different recurrence risks, and present a definite therapeutic response to BRAF inhibitor targeted drugs.
DETECTED TARGETS


The kit utilizes multiplex fluorescent PCR technology for the qualitative detection of three prevalent KIAA1549-BRAF gene fusions in RNA extracted from FFPE glioma tissue specimens.





PRODUCT INFORMATION
Product Name
Assay Method
Packing Specification
Compatible Platforms
Specimen Material
KIAA1549-BRAF Fusion Gene Detection Kit
Multiplex Fluorescent PCR
20 Tests/Kit
ABI7500, ABI7300, ABI StepOne Plus, LightCycler480, Bio-Rad CFX96, etc.
FFPE tissue
DETECTION SIGNIFICANCE

This kit supports molecular subtyping and prognostic risk assessment in pediatric low-grade glioma patients. It helps clinicians screen patients eligible for BRAF-targeted therapy and informs individualized targeted treatment planning.

APPLICABLE POPULATION

The intended population is glioma patients, particularly those with pediatric low-grade gliomas.

FEATURES & ADVANTAGES
Stable and Reliable

Stable and Reliable

Mature assay with built-in QC systems for excellent repeatability and consistent results

Easy to Operate

Easy to Operate

Closed-tube detection, no post-PCR processing required

High Sensitivity

High Sensitivity

Accurately detects low-abundance gene fusions to minimize missed detections

Rapid and Efficient

Rapid and Efficient

Simultaneous detection of 3 fusion variants in one run, enabling high-throughput testing

DETECTION PROCESS

1.Nucleic Acid Extraction

2.Sample Loading

3.Instrument Run

4.Report Generation

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